Genotoxicity of Environmental Mutagens in a Drosophila DNA-repair Test.
نویسندگان
چکیده
منابع مشابه
DNA Repair in Drosophila
Both genetic and biochemical approaches have been used to study the molecular mechanisms by which damaged DNA is repaired in a number of species. The fundamental DNA repair pathways have been functionally conserved for the most part among prokaryotes, lower eukaryotes, and higher eukaryotes, and the proteins and protein families involved in these repair processes show high degrees of amino acid...
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Twenty-eight mycotoxins were studied in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. DNA repair synthesis was elicited by several compounds of unknown carcinogenicity, 5,6- dimethoxysterigmatocystin , versicolorins A and B, averufin , xanthomegnin , luteosporin , and chrysazin , as well as by the carcinogenic myocotoxins , aflatoxin B1, sterigmatocystin, luteo...
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BACKGROUND Many bacterial or mammalian cell-based test systems, such as the Ames test, chromosomal aberration assays, or gene mutation assays, are commonly used in developed countries to detect the genotoxicity of industrial chemicals. However, the specificity is generally limited and the sensitivity is not sufficiently high. In addition, most assays cannot provide information on mechanisms of ...
متن کاملDNA Repair in Drosophila : Insights from the Drosophila Genome Sequence
Both genetic and biochemical approaches have been used to study the molecular mechanisms by which damaged DNA is repaired in a number of species. The fundamental DNA repair pathways have been functionally conserved for the most part among prokaryotes, lower eukaryotes, and higher eukaryotes, and the proteins and protein families involved in these repair processes show high degrees of amino acid...
متن کاملDNA Repair: Nucleotide excision–repair in the test tube
The eukaryotic nucleotide excision-repair pathway has been reconstituted in vitro, an achievement that should hasten the full enzymological characterization of this highly complex DNA-repair pathway.
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ژورنال
عنوان ژورنال: Eisei kagaku
سال: 1993
ISSN: 0013-273X
DOI: 10.1248/jhs1956.39.6_577